The Detroit rapper also took the award for "Best Hip Hop", an honour which he appeared to find slightly baffling.
How to broadcast voice messages to your Google Home speakers
Meanwhile, devices should be updated to version 1.26.9393 and have Do Not Disturb off. Google does note that anyone, not just Voice Match users, can broadcast a message.
"I'm not really sure how I got this, 'cause I haven't had an album out in a few years" he quipped in his acceptance speech, adding "I got one coming though".
"Look What You Made Me Do", singer Taylor Swift had been the most-nominated star of the evening, with six nominations, but failed to win any awards.
The show featured plenty of visual dazzle, from the 50 dancers accompanying Demi Lovato on "Sorry Not Sorry" and "Tell me You Love Me" to the giant animatronic bird carrying Travis Scott onto the stage.
Freeman "unlikely" to play Week 11
Atlanta Falcons running back Devonta Freeman and Dallas Cowboys linebacker Sean Lee both left Sunday's game with injuries. With Freeman out, the Falcons got a solid performance from Coleman (20 yards , 83 yards rushing, 1 TD).
Coldplay was named best rock act, while the best-alternative prize went to Thirty Seconds to Mars. "Congratulations to all the winners and thank you to the wonderful crowd!" He said: "Thank you".
"Their songs are prayers, their concerts a church", he said.
All set for antibiotics awareness week
Antibiotic resistance "It is important that the public is aware that globally we are running out of effective antibiotics". They will also help in identifying the bacteria that make people sick and specific groups that are at risk.
Mendes, 19, who launched his career by posting song covers to the internet before getting signed to a record label, also scooped the "biggest fans" award. And in a nod to a new generation of artists, Bono crooned an a capella version of Stormzy's "Blinded by Your Grace".