"Yes we are going to rest some players", admitted Pochettino. But midfielder Dele Alli, who missed the first three group matches due to suspension, will start and academy graduates Luke Amos and Kazaiah Sterling have been included in the squad.
With Tottenham having only won one of their last five games in all competitions, Pochettino said Luke Amos and Kazaiah Sterling will be among those involved against the Cypriot side, who can not qualify but are battling with Borussia Dortmund for third place. "Tomorrow's a great opportunity for (other) players to show the fans they deserve a place in the team". However, Pochettino believes his players may have taken their eyes off the ball in the Premier League.
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"It's not unusual for a team to have a dip in form", the 21-year-old told Sky Sports News on Tuesday.
"There's nothing to worry about for us".
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"I'm not going to complain, if Sanchez is out for a few games, that's football", said Pochettino.
"When people criticise us, my staff and my team, that always makes you stronger, and sometimes that's good".
"We are focused on this game because it's so important to win, important to finish the Champions League well and it's so important to build our momentum again".
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Writing in his column for BetVictor, ex-striker Owen said: "No Cypriot side has beaten English opposition in European competition and I can't see Apoel bucking that trend at Wembley".