Anthony Joshua's heavyweight rival will top the bill at the Barclays Center, Brooklyn, making the seventh defence of the coveted WBC title he won back in January 2015.
The event is part of Premier Boxing Champions.
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The pair were scheduled to fight back in November but Ortiz tested positive for a banned substance and the much-anticipated bout was cancelled. Bermane Stiverne, the man Wilder took the title from, stepped in but was stopped inside an explosive first round.
After the World Boxing Council conducted an investigation, the boxer was cleared after it the sanctioning body determined that Ortiz's failed test was the direct result of his prescribed medication for high blood pressure.
Wilder (39-0, 38 KOs) is coming off a first-round knockout of Bermane Stiverne in November.
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The victor of the contest could very well land themselves an opportunity against the victor of Anthony Joshua v Joseph Parker in a contest for all the belts available in the heavyweight division, with the proposed clash anticipated set for the March 31st in Cardiff.
Joshua says his goal is to unify the titles and fight all champions by the end of this year.
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