When Trump threatened in October to abandon the Iran deal, the UK, France and Germany said in a joint statement that they remained committed to the pact, formally known as the Joint Comprehensive Plan of Action, and to its full implementation by all sides.
Many European leaders have made clear for months that they agree with global inspectors that Iran is abiding by limits on its nuclear program set out in the deal it made with the US under former President Barack Obama and five other world powers.
On Friday, Trump said the United States would withdraw from the Iranian nuclear deal unless its "disastrous flaws" were fixed.
But Trump, who must meet regular deadlines to endorse the deal every 90 days and approve sanctions waivers every 120 and 180 days, has railed against the agreement. "My impression talking to Europeans is, yes, they want to salvage the deal", but imposing new requirements on Iran may give it reason to walk away.
However, when Trump was elected, Riyadh and Tel Aviv found a new strong ally in their quest to discredit the deal and lobby the US government against the Iranian government.
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Trump, who has sharply criticized the deal reached during Democrat Barack Obama's presidency, had privately chafed at having to once again waive sanctions on a country he sees as a rising threat in the Middle East.
Mr Trump has also approved sanctions against the head of Iran's judiciary, Sadeq Larijani, who the administration holds culpable for the violent crackdown on recent anti-government protests. Trita Parsi, head of the National Iranian American Council, called it a "temporary stay of execution". "And if at any time I judge that such an agreement is not within reach, I will withdraw from the deal immediately", Trump said in a statement.
"The United States will not stand by while the Iranian regime continues to engage in human rights abuses and injustice", Treasury Secretary Steve Mnuchin said in a statement. However, Kelsey Davenport, director of nonproliferation policy, warned that Trump "is setting up the United States to violate it down the road", noting that "threatening to withhold future sanctions waivers in an attempt to force unilateral changes to the deal is risky, jeopardizes the future of the agreement, and creates a schism between the United States and its allies".
The 2015 deal, he said, "is not renegotiable".
"This could be one of Washington's major foreign political mistakes, one of the major miscalculations of America's policy", Ryabkov said.
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That doesn't seem likely to happen; the other European nations in the agreement don't want to renegotiate the deal without Iran's consent - and Iran's foreign minister says the deal "is not renegotiable".
"The Trump regime's hostile action.crossed all red lines of conduct in the global community and is a violation of worldwide law and will surely be answered by a serious reaction of the Islamic Republic", Iran's Foreign Ministry said in a statement carried by state media.
"Trump has once again avoided the nuclear option on the nuclear deal". "Rather than repeating exhausted rhetoric, United States must bring itself into full compliance - just like Iran".
European signatories to the deal have pressured the United States to stick to the accord.
A decision to withhold a waiver would have effectively ended the deal that limits Iran's nuclear program.
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Trump's cancellation was met with humour on social media, with parodies of the president's tweet trending on Twitter. "Just like the rest of the country, we woke up to the news of Trump having canceled his visit", Treacy said.
The deal on Iran's nuclear program was reached between Iran and six global mediators (the United Kingdom, Germany, China, Russia, the United States, and France) on July 14, 2015. "There are many activities outside of the Iran deal, whether it be ballistic missiles, whether it be other issues, that we will continue to sanction, that are outside the JCPOA".