They seem to be powering to the title but, of all teams, Liverpool are considered one of the most likely to threaten their unbeaten record. Manchester City would pay +120 on a road win and +260 if this game plays out to a draw.
Liverpool were on the front foot against Manchester City in September before Sadio Mane's sending off changed the game - but how did they do it and can it be done again?
It remains to be seen if Liverpool will be as adventurous, although with home advantage and the pace of Salah and Mane, they have the players to do real damage.
In one of the most exciting showdowns in the English Premier League this 2018, Liverpool and Manchester City - two of the top sides at the moment - go head-to-head on super Sunday as the English club football top tier competition returns after a week.
This time they will have Virgil van Dijk in their way with the Liverpool defender set to make his Premier League debut after his move from Southampton.
"I think he's more mature".
Henry also gave his verdict on Coutinho's departure.
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City manager Guardiola said: "Normally when this kind of reaction happens it is because he was loved by the fans". The Over-Under, or total number of goals oddsmakers think will be scored, is 3, unchanged from the open.
'Liverpool remain a top, top, top team.
Read Thierry's full verdict here.
Manchester City, which now sits 15 points clear of the second place United, is the only undefeated team left in the Premier League.
City look nailed on to be crowned champions for the first time in four years, having dropped only four points all season.
"I couldn't say Man United is not my club, it didn't feel right".
However, Klopp was coy in his response on Van Dijk's involvement for Sunday's blockbuster clash.
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The Australians will be overly confident after their 4-0 demolition job in the recently completed Ashes . However, more or less, they have been able to stay right on top due to their right team combinations.
"We focus, as always, on ourselves in the first instance, and when we do that we see a team that has performed to the highest level this season and is continuing to grow and get better as the campaign progresses".
Does Manchester City's record at Anfield provide hope for Liverpool?
Since that victory they have lost 10 and drawn four of the meetings at Anfield, taking four points from a possible 42.
Any team willing to press and attack City have found success, and they have found the net.
Manchester City have just been absolutely brilliant but this will be a tough test for them.
Sane did not consider quitting the Veltins-Arena to join Borussia Dortmund as a youngster, though, and he also rejected advances from Liverpool ahead of agreeing to sign for Man City 18 months ago.
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