Burkhead injured his knee in a 27-24 win over the Pittsburgh Steelers on December 17.
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After a very quiet opening to the Selhurst Park clash, Wilfried Zaha set up Sako whose first-time effort was blocked. "Anything else would be a huge bonus, especially having started with seven games, seven defeats and no goals".
It looks like Burkhead will have to wait a little longer, and if New England can't take care of business on Saturday evening, he'll have to wait a whole lot longer than that for his return.
The Patriots will play host to the Titans at 8:15 p.m. ET.
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White will resume his usual role on passing downs, but Lewis should see upwards of 20 carries as the team's primary running back versus the Titans.
Meanwhile, Gillislee has made most of his impact in the running game in his first season with the Patriots rushing for 383 yards and five touchdowns in nine games played. Dealing with a shoulder issue, Hogan missed seven of the final eight games of the season. Burkhead not only rushed for 264 yards and five touchdowns, but he also recorded 254 receiving yards and caught three touchdowns.
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The absence of Burkhead and Gillislee leaves the Patriots with just White, Dion Lewis and Brandon Bolden in the backfield.