Marouane Fellaini is pushing for a recall if Pogba misses out after recovering from a knee injury but Ander Herrera, Marcos Rojo, Phil Jones and Daley Blind remain sidelined.
Jose Mourinho has rotated between Ashley Young and Luke Shaw at left back, but following the former's excellent performance on Saturday - when he quelled the attacking threat of Liverpool's star player Mohamed Salah - the Portuguese tactician is expected to keep Young at left back.
"Do I have the ideal team for Champions League success?"
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The Frenchman missed Saturday's 2-1 win against Liverpool after sustaining a kick in the "very last minute" of Friday's training session.
United fans will be hoping that their side follow the example of Bayern Munich in 2015 when they drew 0-0 in the first leg of their last-16 clash with Shakhtar Donetsk.
'I think he will stay, ' Mourinho told La Sexta.
United drew 0-0 with Sevilla in the first leg and must win tonight to progress to the quarter-finals of the competition.
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"I think when a team gets into the last eight the feeling is you are [competing] among the best but anything can happen".
Rashford has scored three times in seven Champions League games this term, and he'll be aiming to add to that record if given the chance to do so against Sevilla. Mourinho retaliated against Frank de Boer for the criticism made by the Dutchman, and absolutely destroyed the Dutchman.
"We need to score one goal", said the 43-year-old in his pre-match conference.
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The Proteas resumed at 7-263 on Sunday morning in Port Elizabeth , with de Villiers unbeaten on 74 and their lead just 20 runs. He represented South Africa at schoolboy level and at under-19, and won the under-19 World Cup in 2014.