The Supreme Court in the United Kingdom denied on Friday the latest appeal by the parents of a toddler on life support to keep him alive.
There was no reason for further delay, the justices said, adding: "The hospital must be free to do what has been determined to be in Alfie's best interests".
Alfie's parents wanted to move their son from Alder Hey to a hospital in Rome.
They continued: "It has been conclusively determined that it is not in Alfie's best interests, not only to stay in Alder Hey hospital being treated as he now is, but also to travel overseas for the same objective".
He noted, however, that "Alfie is a British citizen and Italy respects the decisions made in the framework of British national jurisdiction" and that "the British national healthcare system and medical standards are among the highest in the world".
The court also refused permission for the parents to appeal the decision.
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"It means that Alfie can not breathe, or eat, or drink without sophisticated medical treatment", the judges continued.
"We have instructed our lawyers to submit an urgent application to the European Court of Human Rights, and they have done so today". It means that Alfie can not breathe, ore eat, or drink without sophisticated medical treatment. Still, Alfie Evans' embattled father and mother fight on.
Alfie's parents filed a petition to the Supreme Court after the UK Court of Appeal ruled this Monday against the parents' argument that their son was being unlawfully detained by the hospital.
It means "there is no hope of his ever getting better", the judges added.
"Like all Alfie's family, I am very disappointed by the new decision of the Supreme Court which justifies Alfie's imprisonment in Alder Hey Hospital, and refuses to let him go to Rome on the invitation of the Pope", Evans said.
It added: 'We understand that this decision is very distressing for Alfie's family at this very hard time'.
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We want to acknowledge the professionalism and career at Alder Nye hospital and cf oc course many of those staff are Catholic.
Mr Evans met Pope Francis on Wednesday morning this week with the pontiff offering prayers and support.
We know that chaplaincy care has be proved and the chaplains are involved in the care of the family so we would want to offer our prayers and concern for everybody in this situation. Francis later mentioned Alfie during his weekly general audience gathering in St Peter's Square, saying: "The only master over life is God".
Alfie is in a "semi-vegetative state" as the result of a degenerative neurological condition that doctors have been unable to definitively identify.
Church teaching says that no-one should be deprived of the "ordinary means" to preserve life such as food, water and medical care, although the catechism points out that "Discontinuing medical procedures that are burdensome, dangerous, extraordinary, or disproportionate to the expected outcome can be legitimate".
Weather week ahead: Big Tuesday warm up & potentially stormy weekend
Tuesday will become windy and a little cooler as highs go back into the 50s and we'll have a chance of some rain showers. Both Saturday and Sunday will be sunny with a high daytime temperatures in the mid-50s, the weather service said.