Authorities say they're trying to figure out whether the explosion was accidental or intentional.
The fire at the building at 11 Mareblu - an outpatient medical clinic - was quickly doused following the roughly 1:10 p.m. explosion.
Sheriff's officials said the size of blast made it suspicious.
Authorities initially indicated a auto had crashed into the building, but Orange County Fire Authority Capt.
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The sheriff's department is partnering with the FBI, the Department of Homeland Security, and the Bureau of Alcohol, Tobacco, Firearms and Explosives, who will assist the investigation.
Officials originally believed the explosion was caused by a auto crashing into the building, but Orange County Sheriff's Department spokeswoman Carrie Braun said no vehicle was involved and the department was investigating how the explosion occurred. "We have an explosion, which is not a common thing".
Orange County Sheriff's Cmdr.
Authorities have not yet found explosive devices in the area, according to officials. The extent of the injuries was not immediately known. OCFA said a bomb squad was sent in to assess the situation and investigate the cause of the blast. The person who died was inside the building when the blast occurred.
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"The corner of that building, the whole bottom floor is pretty much blown out", fire Capt. The injured were taken to a hospital.
Witnesses told the local station that she saw two people, completely covered in ash, exiting the building with singed hair and skin peeling off their wrists. No children were injured, officials said.
Although the cause of the blast was still unknown, Bommarito told reporters around 3:30 p.m. that there was "no immediate hazard" to the community.
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