DMK chief Karunanidhi is on continuous monitoring and being treated with active medical support, the hospital added.
On Sunday, President Ramnath Kovind visited the former Chief Minister at the hospital and wished him speedy recovery. "Maintaining his vital organ functions continues to remain a challenge considering his age related ailments".
Supporters reacting with grief outside of the hospital after the death of revered 94-year-old political leader Muthuvel Karunanidhi. "His response to the medical interventions over the next 24 hours will determine the prognosis", executive director of the hospital Dr Aravindan Selvaraj said in the release.
He was admitted to the hospital for a dip in his blood pressure, which seems to have stabilised now.
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As his political career was taking off, Karunanidhi also became a popular screenwriter for Tamil films.
Expressing her sorrow, Lok Sabha Speaker Sumitra Mahajan said, "He was a great leader, who worked for the downtrodden". He tweeted: "Deeply saddened by passing away of Kalaignar Karunanidhi. We have lost a deep-rooted mass leader, prolific thinker, accomplished writer and a stalwart whose life was devoted to the welfare of the poor and the marginalised".
Born on June 3, 1924 at Thirukkuvalai into a family of Nadaswaram exponents who had traditionally played in temples, Karunanidhi, who was inclined towards Periyar E.V. Ramasamy's atheism and rationalism, joined his self-respect movement as a teenager. Roads outside the hospital and at Karunanidhi's residence were packed with people.
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The same year he parted with 50% of the seats to the Congress in the Assembly elections but the alliance was not fruitful and MGR won.
Karunanidhi holds the record of not losing a single election since then.
On July 27, 1969, he became the party President. In 2016, DMK became the largest Opposition party in the Tamil Nadu Assembly. He was also instrumental in constructing a 133-foot-high statue of Thiruvalluvar, the famous poet, in Kanyakumari.
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13 May 1996 - 13 May 2001: 4th term as chief minister.